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Is Xanax 5 mg b.i.d. a customary dose of this?

Posted By: SM on 2007-03-26
In Reply to:

Subject: Is Xanax 5 mg b.i.d. a customary dose of this?

Just wondering, I am used to transcribing 0.5 mg or 1 mg, 2 mg at the most but I have a resident saying 5 mg b.i.d.  I'm not a doctor so I don't want to pretend I know better, but would you flag this to be sure it was 5 and not 0.5 if you were me?   Maybe they do prescribe as high as 5 mg and just because I have never typed that high of a dose doesn't mean anything, but I always worry, same as when they dictate mg for something that I'm used to typing mcg.  Any opinions?


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Subject: I would flag it, 5 mg b.i.d. is not a normal dose

Here's some info copied and pasted from my QuickLook drug reference.  It looks like 4 mg a day total is about the highest dose.




Usual Dosage

Oral: Note: Treatment >4 months should be re-evaluated to determine the patient's continued need for the drug
Adults:
Anxiety: Immediate release: Effective doses are 0.5-4 mg/day in divided doses; the manufacturer recommends starting at 0.25-0.5 mg 3 times/day; titrate dose upward; maximum: 4 mg/day
Anxiety associated with depression: Immediate release: Average dose required: 2.5-3 mg/day in divided doses
Panic disorder:
Immediate release: Initial: 0.5 mg 3 times/day; dose may be increased every 3-4 days in increments ≤1 mg/day; many patients obtain relief at 2 mg/day, as much as 10 mg/day may be required
Extended release: 0.5-1 mg once daily; may increase dose every 3-4 days in increments ≤1 mg/day (range: 3-6 mg/day)
Switching from immediate release to extended release: Patients may be switched to extended release tablets by taking the total daily dose of the immediate release tablets and giving it once daily using the extended release preparation.
Preoperative sedation: 0.5 mg in evening at bedtime and 0.5 mg 1 hour before procedure
Dose reduction: Abrupt discontinuation should be avoided. Daily dose may be decreased by 0.5 mg every 3 days, however, some patients may require a slower reduction. If withdrawal symptoms occur, resume previous dose and discontinue on a less rapid schedule.



Dosage Forms


Solution, oral (Alprazolam Intensol®): 1 mg/mL (30 mL)
Tablet (Xanax®): 0.25 mg, 0.5 mg, 1 mg, 2 mg
Tablet, extended release (Xanax XR®): 0.5 mg, 1 mg, 2 mg, 3 mg
Tablet, orally-disintegrating (Niravam™): 0.25 mg, 0.5 mg, 1 mg, 2 mg [orange flavor]